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	Provedor de dados Biocell (2) Autor Hong,Samin (2) Je Seong,Gong (1) Kab Kim,Seung (1) Kim,Chan Yun (1) Park,Kyoungsoo (1) Seong,Gong Je (1) Yoko,Iizuka (1) Yun Kim,Chan (1) Mais... Palavra-chave Agmatine (1) Apoptosis (1) Hypoxia (1) Neuronal damage (1) Neuroprotection (1) Retinal ganglion cell (1) Tumor necrosis factor-alpha (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2008 (2) País Argentina (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells Biocell Hong,Samin; Park,Kyoungsoo; Kim,Chan Yun; Seong,Gong Je. The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100μM agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic... Tipo: Info:eu-repo/semantics/other Palavras-chave: Retinal ganglion cell; Tumor necrosis factor-alpha; Hypoxia; Agmatine. Ano: 2008 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006 Agmatine pretreatment protects retinal ganglion cells (RGC-5 cell line) from oxidative stress in vitro Biocell Yoko,Iizuka; Hong,Samin; Yun Kim,Chan; Kab Kim,Seung; Je Seong,Gong. Agmatine, 2-(4-aminobutyl)guanidine, has been reported to have neuroprotective effects against various neuronal damages. In this study it was investigated whether agmatine pretreatment rescues the retinal ganglion cells from oxidative injury in vitro. After differentiation of transformed rat retinal ganglion cells (RGC-5 cell line) with staurosporine, agmatine (0.0 to 100.0 μM) pretreatment was performed for 2 hours. Subsequently, they were exposed to hydrogen peroxide (0.0 to 2.5 mM) as an oxidative stress. Cell viability was monitored for up to 48 hours with the lactate dehydrogenase (LDH) assay and apoptosis was examined by the terminal deoxynucleotide transferase-mediated terminal uridine deoxynucleotidyl transferase nick end-labeling (TUNEL)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuronal damage; Apoptosis; Neuroprotection. Ano: 2008 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000300005 Registros recuperados: 2 Primeira ... 1 ... Última

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